11:52 PM ET
Jazz center Rudy Gobert was attempting to drive on Jokic along the baseline in the second quarter when he banged knees with him. Jokic went down almost immediately and was in a great deal of pain as he held his right knee area.
He left the game with 1:54 remaining in the second quarter.
Jokic was initially listed as questionable to return by the team. After halftime, Jokic was on the court for warmups but did not start the second half. He was later ruled out for the remainder of the contest.
The Nuggets are already without star guard Jamal Murray, who is recovering from a torn ACL suffered last April.
Jokic won his first MVP award last season and is off to a hot start.